Players with state ties selected in the 2025 MLB Draft
(* means freshman signer or commitment)
| CADEN | BODINE | C | COASTAL CAROLINA | 1 (round) | 30 (pick #) | ORIOLES |
| DAX | KILBY | SS | CLEMSON* | 1 | 39 | YANKEES |
| CAM | CANNARELLA | OF | CLEMSON | 1 | 40 | MARLINS |
| ETHAN | PETRY | OF | USC | 2 | 49 | NATIONALS |
| JACOB | MORRISON | RHP | COASTAL CAROLINA | 3 | 94 | BREWERS |
| RYAN | WIDEMAN | OF | CLEMSON* | 3 | 99 | PADRES |
| NATHAN | HALL | OF | USC | 5 | 153 | DIAMONDBACKS |
| LUCAS | MAHLSTEDT | RHP | CLEMSON | 7 | 199 | ANGELS |
| RILEY | EIKOFF | RHIP | COASTAL CAROLINA | 9 | 256 | WHITE SOX |
| JAKE | BRINK | RHPI | CHARLESTON | 11 | 324 | REDS |
| ELI | JERZEMBECK | RHIP | USC | 11 | 331 | CUBS |
| TLER | BOWEN | RHP | LANDER | 12 | 371 | PHILLIES |
| CARTER | RASMUSSEN | RHP | WOFFORD | 14 | 418 | RED SOX |
| NOAH | FRANKLIN | C | USC* | 17 | 505 | RANGERS |
| LUKE | ROUPE | RHP | USC* | 17 | 515 | BREWERS |
| BRODEY | FOWELER | RHP | NORTH GREENVILLE | 17 | 517 | BRAVES |
| RICHIE | CORTESE | LHP | LANDER | 17 | 521 | PHILLIES |
| MATTHEW | POTOK | RHP | COASTAL CAROLINA | 18 | 551 | PHILLIES |
| MATTHEW | BECKER | LHP | USC | 19 | 569 | TWINS |
| NICK | FRUSCO | LHP | CLEMSON* | 20 | 593 | PIRATES |